Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to quantify
The discovery that antibodies targeting neuronal antigens can induce severe psychiatric symptoms has been a significant progress in the understanding of psychiatric disorders.Antibodies targeting synapsin I in serum and cerebrospinal fluid (CSF) were first reported in 2015 in a patient with limbic encephalitis.Because of its regulatory function for
Concession agreements in infrastructure have civil and administrative nature making possible for the Government to apply administrative fines and nobivac 1-dappv for puppies liquidated damages provisions in case of concessionaires breach.On the transportation infrastructure side, the authors explain that theoretical and practical misunderstandings
Background: Hydrocephalus is a common complication in tuberculous meningitis patients and is a poor predictor with high mortality and morbidity rates.Therefore, early diagnosis, detection, and treatment of hydrocephalus are important.Cerebrospinal fluid diversion is the process used to drain accumulated fluid in the brain and spinal cord.This study